BioSB 2025 took place from 20 to 21 May at the picturesque Kasteel De Berckt in Baarlo, the Netherlands. The superbly organised conference offered fascinating insights into current research topics and demonstrated once again just how diverse the field of bioinformatics is. Our research group from Düsseldorf was well represented and took the opportunity to engage in intensive scientific exchange, as well as to establish new international relationships and strengthen existing ones.